Respiratory magnetic resonance imaging biomarkers in Duchenne muscular dystrophy.

ABSTRACT:

Objective

To examine the diaphragm and chest wall dynamics with cine breathing magnetic resonance imaging (MRI) in ambulatory boys with Duchenne muscular dystrophy (DMD) without respiratory symptoms and controls.

Methods

In 11 DMD boys and 15 controls, cine MRI of maximal breathing was recorded for 10 sec. The lung segmentations were done by an automated pipeline based on a Holistically-Nested Network model (HNN method). Lung areas, diaphragm, and chest wall motion were measured throughout the breathing cycle.

Results

The HNN method reliably identified the contours of the lung and the diaphragm in every frame of each dataset (~180 frames) within seconds. The lung areas at maximal inspiration and expiration were reduced in DMD patients relative to controls (P =<

SUBMITTER: Mankodi A 

PROVIDER: S-EPMC5590523 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature