Impact of diabetes in the Friedreich ataxia clinical outcome measures study.

ABSTRACT:

Objective

Friedreich ataxia (FA) is a progressive neuromuscular disorder caused by GAA triplet repeat expansions or point mutations in the FXN gene. FA is associated with increased risk of diabetes mellitus (DM). This study assessed the age-specific prevalence of FA-associated DM and its impact on neurologic outcomes.

Research design and methods

Participants were 811 individuals with FA from 12 international sites in a prospective natural history study (FA Clinical Outcome Measures Study, FACOMS). Physical function was assessed, using validated instruments. Multivariable regression analyses examined the independent association of DM with outcomes.

Results

Mean age of participants was 30.1 years (SD 15.3, range: 7-82), 50% were female, and 94% were non-Hispanic

SUBMITTER: McCormick A 

PROVIDER: S-EPMC5590524 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature