Solid tumors are poroelastic solids with a chemo-mechanical feedback on growth.

ABSTRACT: The experimental evidence that a feedback exists between growth and stress in tumors poses challenging questions. First, the rheological properties (the "constitutive equations") of aggregates of malignant cells are still a matter of debate. Secondly, the feedback law (the "growth law") that relates stress and mitotic-apoptotic rate is far to be identified. We address these questions on the basis of a theoretical analysis of in vitro and in vivo experiments that involve the growth of tumor spheroids. We show that solid tumors exhibit several mechanical features of a poroelastic material, where the cellular component behaves like an elastic solid. When the solid component of the spheroid is loaded at the boundary, the cellular aggregate grows up to an asymptotic volume that de

SUBMITTER: Ambrosi D 

PROVIDER: S-EPMC5590729 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature