Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity.

ABSTRACT: Lung-resident memory CD8 T cells (T_RM) induced by influenza A virus (IAV) that are pivotal for providing subtype-transcending protection against IAV infection (heterosubtypic immunity) are not maintained long term, causing gradual loss of protection. The short-lived nature of lung T_RM contrasts sharply with long-term maintenance of T_RM induced by localized infections in the skin and in other tissues. We show that the decline in lung T_RM is determined by an imbalance between apoptosis and lung recruitment and conversion to T_RM of circulating memory cells. We show that circulating effector memory cells (T_EM) rather than central memory cells (T_CM) are the precursors for conversion to lung T_RM Time-dependen

SUBMITTER: Slutter B 

PROVIDER: S-EPMC5590757 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature