Ontology highlight
ABSTRACT:
SUBMITTER: Zinski J
PROVIDER: S-EPMC5590806 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zinski Joseph J Bu Ye Y Wang Xu X Dou Wei W Umulis David D Mullins Mary C MC
eLife 20170809
A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral embryonic axis of vertebrates and invertebrates. The prevailing view in vertebrates for BMP gradient formation is through a counter-gradient of BMP antagonists, often along with ligand shuttling to generate peak signaling levels. To delineate the mechanism in zebrafish, we precisely quantified the BMP activity gradient in wild-type and mutant embryos and combined these data with a mathematical model-base ...[more]