Defining the biological basis of radiomic phenotypes in lung cancer.

ABSTRACT: Medical imaging can visualize characteristics of human cancer noninvasively. Radiomics is an emerging field that translates these medical images into quantitative data to enable phenotypic profiling of tumors. While radiomics has been associated with several clinical endpoints, the complex relationships of radiomics, clinical factors, and tumor biology are largely unknown. To this end, we analyzed two independent cohorts of respectively 262 North American and 89 European patients with lung cancer, and consistently identified previously undescribed associations between radiomic imaging features, molecular pathways, and clinical factors. In particular, we found a relationship between imaging features, immune response, inflammation, and survival, which was further validated by immunohistochem

SUBMITTER: Grossmann P 

PROVIDER: S-EPMC5590809 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature