Colonic cytomegalovirus detection by mucosal PCR and antiviral therapy in ulcerative colitis.

ABSTRACT:

Background

We aimed to identify the risk factors associated with colonic cytomegalovirus (CMV) infection in ulcerative colitis (UC) and to compare the clinical course between antiviral therapy-treated and -untreated groups in mucosal CMV-polymerase chain reaction (PCR) -positive cases.

Methods

We retrospectively selected 46 UC patients (>15 years old) in active phase who underwent colonoscopy with biopsy and were analyzed for CMV infection by mucosal PCR between October 2011 and December 2015 at our institution. Colonic CMV in inflamed mucosa was detected using quantitative real-time PCR. The clinical course was evaluated, including need for drug therapy/surgery or drug therapy intensification. In addition, we evaluated the clinical course between CMV-DNA- cases and CMV-DNA+

SUBMITTER: Okahara K 

PROVIDER: S-EPMC5590814 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature