Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans.

ABSTRACT:

Introduction

Toll-like receptor 9 (TLR9) is an innate immune system DNA-receptor that regulates tumor invasion and immunity in vitro. Low tumor TLR9 expression has been associated with poor survival in Caucasian patients with triple negative breast cancer (TNBC). African American (AA) patients with TNBC have worse prognosis than Caucasians but whether this is due to differences in tumor biology remains controversial. We studied the prognostic significance of tumor Toll like receptor-9 (TLR9) protein expression among African American (AA) triple negative breast cancer (TNBC) patients. Germline TLR9 variants in European Americans (EAs) and AAs were investigated, to determine their contribution to AA breast cancer risk.

Methods

TLR9 expression was studied with immunohistochemis

SUBMITTER: Chandler MR 

PROVIDER: S-EPMC5590816 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature