CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.

ABSTRACT: Cardiac progenitors are specified early in development and progressively differentiate and mature into fully functional cardiomyocytes. This process is controlled by an extensively studied transcriptional program. However, the regulatory events coordinating the progression of such program from development to maturation are largely unknown. Here, we show that the genome organizer CTCF is essential for cardiogenesis and that it mediates genomic interactions to coordinate cardiomyocyte differentiation and maturation in the developing heart. Inactivation of Ctcf in cardiac progenitor cells and their derivatives in vivo during development caused severe cardiac defects and death at embryonic day 12.5. Genome wide expression analysis in Ctcf mutant hearts revealed that genes controlling mitochond

SUBMITTER: Gomez-Velazquez M 

PROVIDER: S-EPMC5591014 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature