Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium.

ABSTRACT:

Background

Interleukin (IL)-33 is implicated in the pathophysiology of asthma and allergic diseases. However, our knowledge is limited regarding how IL-33 release is controlled. The transcription factor nuclear factor-erythroid-2-related factor 2 (Nrf2) plays a key role in antioxidant response regulation.

Objective

The goal of this project was to investigate the role of cellular oxidative stress in controlling IL-33 release in airway epithelium.

Methods

Complementary approaches were used that included human bronchial epithelial cells and mouse models of airway type-2 immunity that were exposed to fungus Alternaria extract. The clinically available Nrf2 activator 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid methyl ester (CDDO-Me) was used to evaluate the role of Nrf2-

SUBMITTER: Uchida M 

PROVIDER: S-EPMC5591045 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature