Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention.

ABSTRACT: Answer questions and earn CME/CNE Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25-29.9 kg/m² ), and of these, over 600 million were obese (BMI ≥30 kg/m² ). Although the association between obesity and the risk of diabetes and coronary artery disease is widely known, the impact of obesity on cancer incidence, morbidity, and mortality is not fully appreciated. Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages. The first part of this review summarizes the relationships between obesity and breast cancer

SUBMITTER: Picon-Ruiz M 

PROVIDER: S-EPMC5591063 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature