Polymer-spray mass spectrometric detection and quantitation of hydrophilic compounds and some narcotics.

ABSTRACT:

Rationale

High-throughput screening of biofluids is essential in monitoring concentration of a variety of drugs to determine their efficacy and toxicity. Organosiloxane polymers prepared by sol-gel chemistry as sample supports, and electrospray ionization emitters in a single material and as an alternative to paper substrates, is described in this study.

Methods

Hydrophobic drugs and hydrophilic streptomycin were analyzed by polymer-spray mass spectrometry with an LTQ-Orbitrap mass spectrometer. Drug samples in urine (1-2 μL) were deposited on an OSX polymer, allowed to dry, then electrosprayed from the polymer tip into the mass spectrometer without sample pretreatment. The OSX polymers, whose polarity and porosity can be controlled, were prepared by sol-gel chemistry where

SUBMITTER: Dulay MT 

PROVIDER: S-EPMC5591076 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature