Case report: Brincidofovir-induced reversible severe acute kidney injury in 2 solid-organ transplant for treatment of cytomegalovirus infection.

ABSTRACT:

Rationale

Resistant cytomegalovirus-mediated infections are increasing in solid organ recipient with few available alternative treatments. Brincidofovir is an oral broad-spectrum antiviral in development for prevention and treatment of viral infection, particularly cytomegalovirus.

Patients concerns

Although brincidofovir is an analogue of cidofovir, previous studies reported no renal toxicity.

Diagnoses

Here, we report 2 cases of severe tubular necrosis in solid organ recipients, 1 heart and 1 kidney transplant.

Interventions

Both patients received brincidofovir for the treatment of cytomegalovirus infection with mutation of UL-97. They presented an acute kidney injury without any occurrence of other clinical event such as introduction of nephrotoxic drug, gra

SUBMITTER: Faure E 

PROVIDER: S-EPMC5591119 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature