Ontology highlight
ABSTRACT:
SUBMITTER: Schweitzer B
PROVIDER: S-EPMC5591221 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Schweitzer Barbara B Singh Jeet J Fejtova Anna A Groc Laurent L Heine Martin M Frischknecht Renato R
Scientific reports 20170908 1
Cortical areas of the juvenile rodent brain display a high degree of structural and functional plasticity, which disappears later in development. Coincident with the decline of plasticity 1) the hyaluronic acid-based extracellular matrix (ECM) of the brain, which stabilizes synapses and neuronal circuit is formed and 2) N-methyl-D-aspartate subtype of ionotropic glutamate receptors (NMDARs) implied in synaptic plasticity switch from mainly GluN2B to GluN2A subunit-containing receptors. Here we t ...[more]