Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations.

ABSTRACT: Serum biomarker levels are associated with the risk of complex diseases. Here, we aimed to gain insights into the genetic architecture of biomarker traits which can reflect health status. We performed genome-wide association analyses for twenty serum biomarkers involved in organ function and reproductive health. 9,961 individuals from the UK Household Longitudinal Study were genotyped using the Illumina HumanCoreExome array and variants imputed to the 1000 Genomes Project and UK10K haplotypes. We establish a polygenic heritability for all biomarkers, confirm associations of fifty-four established loci, and identify five novel, replicating associations at genome-wide significance. A low-frequency variant, rs28929474, (beta = 0.04, P = 2 × 10^-10) was associated with levels of alan

SUBMITTER: Prins BP 

PROVIDER: S-EPMC5591265 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature