Metabolomics As a Tool for the Characterization of Drug-Resistant Epilepsy.

ABSTRACT:

Purpose

Drug resistance is a critical issue in the treatment of epilepsy, contributing to clinical emergencies and increasing both serious social and economic burdens on the health system. The wide variety of potential drug combinations followed by often failed consecutive attempts to match drugs to an individual patient may mean that this treatment stage may last for years with suboptimal benefit to the patient. Given these challenges, it is valuable to explore the availability of new methodologies able to shorten the period of determining a rationale pharmacologic treatment. Metabolomics could provide such a tool to investigate possible markers of drug resistance in subjects with epilepsy.

Methods

Blood samples were collected from (1) controls (C) (n = 35), (2) pati

SUBMITTER: Murgia F 

PROVIDER: S-EPMC5591409 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature