Pharmacogenetics and the treatment of functional gastrointestinal disorders.

ABSTRACT: The diagnosis and management of functional gastrointestinal disorders (FGIDs) remain very challenging. In the era of precision medicine, it is important to individualize the treatment of these conditions by providing targeted and effective therapies while minimizing the risk of medication side effects. By using genetic information that predicts and affects the responses to specific medications, it is anticipated that the science of pharmacogenetics in FGIDs will advance the practice of precision medicine. The pathophysiology of FGIDs is complex, involving the interaction between predisposing genetic and environmental factors. Studies have shown that genetic polymorphisms may contribute to the variable responses to specific medications among individuals with FGIDs. Genetic variations in the

SUBMITTER: Halawi H 

PROVIDER: S-EPMC5591464 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature