Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma.

ABSTRACT:

Background

Severe equine asthma is a naturally occurring lung inflammatory disease of mature animals characterized by neutrophilic inflammation, bronchoconstriction, mucus hypersecretion and airway remodeling. Exacerbations are triggered by inhalation of dust and microbial components. Affected animals eventually are unable of aerobic performance. In this study transcriptomic differences between asthmatic and non-asthmatic animals in the response of the bronchial epithelium to an inhaled challenge were determined.

Results

Paired endobronchial biopsies were obtained pre- and post-challenge from asthmatic and non-asthmatic animals. The transcriptome, determined by RNA-seq and analyzed with edgeR, contained 111 genes differentially expressed (DE) after challenge between horses w

SUBMITTER: Tessier L 

PROVIDER: S-EPMC5591550 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature