Can Randall's plug composed of calcium oxalate form via the free particle mechanism?

ABSTRACT:

Background

The likelihood of a Randall's plug composed of calcium oxalate monohydrate (COM) forming by the free particle mechanism in a model of kidney with a structure recently described by Robertson was examined at the most favourable conditions for the considered mechanism.

Methods

The Robertson model of the kidney is used in the following development. The classical theory of crystallization was used for calculations.

Results

Initial COM nuclei were assumed to form at the beginning of the ascending loop of Henle where the supersaturation with respect to COM has been shown to reach the threshold level for spontaneous nucleation. Nucleation proceeds by a heterogeneous mechanism. The formed particles are transported in the nephron by a laminar flow of liquid with a pa

SUBMITTER: Grases F 

PROVIDER: S-EPMC5591557 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature