The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children.

ABSTRACT:

Background

Oxylipins and endocannabinoids are low molecular weight bioactive lipids that are crucial for initiation and resolution of inflammation during microbial infections. Metabolic complications in malaria are recognized contributors to severe and fatal malaria, but the impact of malaria infection on the production of small lipid derived signalling molecules is unknown. Knowledge of immunoregulatory patterns of these molecules in malaria is of great value for better understanding of the disease and improvement of treatment regimes, since the action of these classes of molecules is directly connected to the inflammatory response of the organism.

Methods

Detection of oxylipins and endocannabinoids from plasma samples from forty children with uncomplicated and severe malar

SUBMITTER: Surowiec I 

PROVIDER: S-EPMC5591560 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature