Impact of post-processing methods on apparent diffusion coefficient values.

ABSTRACT:

Objective

The apparent diffusion coefficient (ADC) is increasingly used as a quantitative biomarker in oncological imaging. ADC calculation is based on raw diffusion-weighted imaging (DWI) data, and multiple post-processing methods (PPMs) have been proposed for this purpose. We investigated whether PPM has an impact on final ADC values.

Methods

Sixty-five lesions scanned with a standardized whole-body DWI-protocol at 3 T served as input data (EPI-DWI, b-values: 50, 400 and 800 s/mm²). Using exactly the same ROI coordinates, four different PPM (ADC_1-ADC_4) were executed to calculate corresponding ADC values, given as [10^-3 mm²/s] of each lesion. Statistical analysis was performed to intra-individually compare ADC values stratified by PPM (Wil

SUBMITTER: Zeilinger MG 

PROVIDER: S-EPMC5591618 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature