Insight into Metabolic ¹H-MRS Changes in Natalizumab Induced Progressive Multifocal Leukoencephalopathy Brain Lesions.

ABSTRACT:

Background

Progressive multifocal leukoencephalopathy (PML) is a severe complication of immunosuppressive therapies, especially of natalizumab in relapsing-remitting multiple sclerosis (MS). Metabolic changes within PML lesions have not yet been described in natalizumab-associated PML in MS patients.

Objective

To study metabolic profiles in natalizumab-associated PML lesions of MS patients by ¹H magnetic resonance spectroscopy (¹H-MRS) at different stages during the PML course. To assess changes associated with the occurrence of the immune reconstitution inflammatory syndrome (IRIS).

Methods

20 patients received ¹H-MRS and imaging at 3 T either in the pre-IRIS, IRIS, early-post-PML, or late post-PML setting. Five of these patients rece

SUBMITTER: Schneider R 

PROVIDER: S-EPMC5591840 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature