"Multi-Omics" Analyses of the Development and Function of Natural Killer Cells.

ABSTRACT: For over four decades, our understanding of natural killer (NK) cells has evolved from the original description of cluster of differentiation (CD)56⁺CD3^- to establishing NK cells as an important subset of innate lymphocytes in the host's surveillance against viral infections and malignancy. The progress of research on the fundamental properties and therapeutic prospects for translational medicine using NK cells excites immunologists and clinicians. Over the past decade, numerous advances in "-omics"-scale methods and new technological approaches have addressed many essential questions in the biology of NK cells. We now have further understanding of the overall molecular mechanisms of action that determine the development, function, plasticity, diversity, and immune re

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5591885 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature