The effect of epigallocatechin-3-gallate on the renal dysfunction in the obstructed kidney in the rat.

ABSTRACT:

Introduction

Epigallocatechin-3-gallate (EGCG) is the most active catechin polyphenol extracted from the green tea. EGCG has protective effects in various renal and non-renal conditions. The aim of this study was to investigate the effect of EGCG on the alterations in renal functional parameters following reversible unilateral ureteral obstruction (UUO) in the rat.

Methods

Wistar rats underwent reversible left UUO for 72 hours. Group-EGCG (n=10) received intraperitoneal 50 mg/kg/day of EGCG whereas Group-Vx (n=10) had only normal saline. Five days post UUO reversal, renal functions of both kidneys were measured using clearance techniques and the gene expression of some of kidney injury markers (KIM-1 and NGL) and the pro-inflammatory mediator (TNF-α) were determined using re

SUBMITTER: Hammad FT 

PROVIDER: S-EPMC5592246 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature