Hydroxysafflor Yellow A Attenuates the Apoptosis of Peripheral Blood CD4⁺ T Lymphocytes in a Murine Model of Sepsis.

ABSTRACT: Sepsis is generally considered as a severe condition of inflammation that leads to lymphocyte apoptosis and multiple organ dysfunction. Hydroxysafflor yellow A (HSYA) exerts anti-inflammatory and anti-apoptotic effects in infectious diseases. However, the therapeutic effect of HSYA on polymicrobial sepsis remains unknown. This study was undertaken to investigate the therapeutic effects and the mechanisms of action of HSYA on immunosuppression in a murine model of sepsis induced by cecal ligation and puncture (CLP). NIH mice were randomly divided into four groups: control group, sham group, CLP group, and CLP+HSYA group. HSYA (120 mg/kg) was intravenously injected into experimental mice at 12 h before CLP, concurrent with CLP and 12 h after CLP. The levels of circulating inflammatory cytoki

SUBMITTER: Wang J 

PROVIDER: S-EPMC5592278 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature