Chromatin-remodeling SWI/SNF complex regulates coenzyme Q₆ synthesis and a metabolic shift to respiration in yeast.

ABSTRACT: Despite its relatively streamlined genome, there are many important examples of regulated RNA splicing in Saccharomyces cerevisiae Here, we report a role for the chromatin remodeler SWI/SNF in respiration, partially via the regulation of splicing. We find that a nutrient-dependent decrease in Snf2 leads to an increase in splicing of the PTC7 transcript. The spliced PTC7 transcript encodes a mitochondrial phosphatase regulator of biosynthesis of coenzyme Q₆ (ubiquinone or CoQ₆) and a mitochondrial redox-active lipid essential for electron and proton transport in respiration. Increased splicing of PTC7 increases CoQ₆ levels. The increase in PTC7 splicing occurs at least in part due to down-regulation of ribosomal protein gen

SUBMITTER: Awad AM 

PROVIDER: S-EPMC5592666 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature