Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline.

ABSTRACT: Compelling evidence suggests that epigenetic mechanisms such as DNA methylation play a role in stress regulation and in the etiologic basis of stress related disorders such as Post traumatic Stress Disorder (PTSD). Here we describe the purpose and methods of an international consortium that was developed to study the role of epigenetics in PTSD. Inspired by the approach used in the Psychiatric Genomics Consortium, we brought together investigators representing seven cohorts with a collective sample size of N = 1147 that included detailed information on trauma exposure, PTSD symptoms, and genome-wide DNA methylation data. The objective of this consortium is to increase the analytical sample size by pooling data and combining expertise so that DNA methylation patterns associated with PTSD ca

SUBMITTER: Ratanatharathorn A 

PROVIDER: S-EPMC5592721 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature