Agonist Binding to Chemosensory Receptors: A Systematic Bioinformatics Analysis.

ABSTRACT: Human G-protein coupled receptors (hGPCRs) constitute a large and highly pharmaceutically relevant membrane receptor superfamily. About half of the hGPCRs' family members are chemosensory receptors, involved in bitter taste and olfaction, along with a variety of other physiological processes. Hence these receptors constitute promising targets for pharmaceutical intervention. Molecular modeling has been so far the most important tool to get insights on agonist binding and receptor activation. Here we investigate both aspects by bioinformatics-based predictions across all bitter taste and odorant receptors for which site-directed mutagenesis data are available. First, we observe that state-of-the-art homology modeling combined with previously used docking procedures turned out to reproduce o

SUBMITTER: Fierro F 

PROVIDER: S-EPMC5592726 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature