Breast tumor DNA methylation patterns associated with smoking in the Carolina Breast Cancer Study.

ABSTRACT:

Purpose

Tobacco smoking is a risk factor in several cancers, yet its roles as a putative etiologic exposure or poor prognostic factor in breast cancer are less clear. Altered DNA methylation contributes to breast cancer development and may provide a mechanistic link between smoking and gene expression changes leading to cancer development or progression.

Methods

Using a cancer-focused array, we examined methylation at 933 CpGs in 517 invasive breast tumors in the Carolina Breast Cancer Study to determine whether methylation patterns differ by exposure to tobacco smoke. Multivariable generalized linear regression models were used to compare tumor methylation profiles between smokers and never smokers, overall, or stratified on hormone receptor (HR) status.

Results

Mode

SUBMITTER: Conway K 

PROVIDER: S-EPMC5592727 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature