Composite iron oxide-Prussian blue nanoparticles for magnetically guided T₁-weighted magnetic resonance imaging and photothermal therapy of tumors.

ABSTRACT: Theranostic nanoparticles offer the potential for mixing and matching disparate diagnostic and therapeutic functionalities within a single nanoparticle for the personalized treatment of diseases. In this article, we present composite iron oxide-gadolinium-containing Prussian blue nanoparticles (Fe₃O₄@GdPB) as a novel theranostic agent for T₁-weighted magnetic resonance imaging (MRI) and photothermal therapy (PTT) of tumors. These particles combine the well-described properties and safety profiles of the constituent Fe₃O₄ nanoparticles and gadolinium-containing Prussian blue nanoparticles. The Fe₃O₄@GdPB nanoparticles function both as effective MRI contrast agents and PTT agents as determined by characterizing stud

SUBMITTER: Kale SS 

PROVIDER: S-EPMC5592912 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature