Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium.

ABSTRACT: The organ of Corti in the cochlea is a two-cell layered epithelium: one cell layer of mechanosensory hair cells that align into one row of inner and three rows of outer hair cells interdigitated with one cell layer of underlying supporting cells along the entire length of the cochlear spiral. These two types of epithelial cells are derived from common precursors in the four- to five-cell layered primordium and acquire functionally important shapes during terminal differentiation through the thinning process and convergent extension. Here, we have examined the role of Six1 in the establishment of the auditory sensory epithelium. Our data show that prior to terminal differentiation of the precursor cells, deletion of Six1 leads to formation of only a few hair cells and defective patterning o

SUBMITTER: Zhang T 

PROVIDER: S-EPMC5593176 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature