Adaptive servo ventilation for central sleep apnoea in heart failure: SERVE-HF on-treatment analysis.

ABSTRACT: This on-treatment analysis was conducted to facilitate understanding of mechanisms underlying the increased risk of all-cause and cardiovascular mortality in heart failure patients with reduced ejection fraction and predominant central sleep apnoea randomised to adaptive servo ventilation versus the control group in the SERVE-HF trial.Time-dependent on-treatment analyses were conducted (unadjusted and adjusted for predictive covariates). A comprehensive, time-dependent model was developed to correct for asymmetric selection effects (to minimise bias).The comprehensive model showed increased cardiovascular death hazard ratios during adaptive servo ventilation usage periods, slightly lower than those in the SERVE-HF intention-to-treat analysis. Self-selection bias was evident. Patient

SUBMITTER: Woehrle H 

PROVIDER: S-EPMC5593355 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature