Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI.

ABSTRACT: Sleep is necessary for the optimal consolidation of newly acquired procedural memories. However, the mechanisms by which motor memory traces develop during sleep remain controversial in humans, as this process has been mainly investigated indirectly by comparing pre- and post-sleep conditions. Here, we used functional magnetic resonance imaging and electroencephalography during sleep following motor sequence learning to investigate how newly-formed memory traces evolve dynamically over time. We provide direct evidence for transient reactivation followed by downscaling of functional connectivity in a cortically-dominant pattern formed during learning, as well as gradual reorganization of this representation toward a subcortically-dominant consolidated trace during non-rapid eye movement (NR

SUBMITTER: Vahdat S 

PROVIDER: S-EPMC5593513 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature