Identification of a novel p53 target, COL17A1, that inhibits breast cancer cell migration and invasion.

ABSTRACT: p53 mutation is a marker of poor prognosis in breast cancers. To identify downstream targets of p53, we screened two transcriptome datasets, including cDNA microarrays of MCF10A breast epithelial cells with wild-type p53 or p53-null background, and RNA sequence analysis of breast invasive carcinoma. Here, we unveil ten novel p53 target candidates that are up-regulated after the induction of p53 in wild-type cells. Their expressions are also high in breast invasive carcinoma tissues with wild-type p53. The GO analysis identified epidermis development and ectoderm development, which COL17A1 participates, as significantly up-regulated by wild-type p53. The COL17A1 expressions increased in a p53-dependent manner in human breast cells and mouse mammary

SUBMITTER: Yodsurang V 

PROVIDER: S-EPMC5593524 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature