Dysregulation of an X-linked primate-specific epididymal microRNA cluster in unexplained asthenozoospermia.

ABSTRACT: Asthenoszoopermia, characterized by reduced sperm motility, is one of the primary forms of male infertility. Whereas most cases were diagnosed into unexplained asthenozoospermia (UA) because the etiology cannot be identified. In animal models, epigenetic dysregulation in epididymis can impair sperm maturation and result in asthenozoospermia. However, researches of epididymal epigenetic regulation on humans are impeded by the difficulty in obtaining epididymal tissues. We previously identified cell-free seminal microRNAs predominately derived from epididymis in human ejaculate. In the present study, these microRNAs were used to screen and validate the microRNA dysregulation in men with UA, which were divided into screening set and validation set. The expression of five miRNAs (miR-891b, miR

SUBMITTER: Qing X 

PROVIDER: S-EPMC5593606 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature