Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies.

ABSTRACT: It is well established that apelin-APLNR (apelin receptor) pathway plays a central role in cardiovascular system. In this meta-analysis, we summarized published results on circulating apelin concentration in association with coronary artery disease (CAD), apelin and APLNR genetic polymorphism(s) in predisposition to CAD risk and circulating apelin changes after surgical treatment for CAD. The results from 15 articles were pooled. Two authors independently took charge of literature search, article selection and information collection. Overall, circulating apelin concentration was significantly lower in CAD patients (N=1021) than in controls (N=654) (weighted mean difference [WMD]: -1.285 ng/mL, 95% confidence interval [CI]: -1.790 to -0.780, P<0001), with significant he

SUBMITTER: Chen T 

PROVIDER: S-EPMC5593646 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature