Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma.

ABSTRACT: A rat model of sarcomatoid mesothelioma, mimicking some of the worst clinical conditions encountered, was established to evaluate the therapeutic potential of intracavitary curcumin administration. The M5-T1 cell line, selected from a collection established from F344 rats induced with asbestos, produces tumors within three weeks, with extended metastasis in normal tissues, after intraperitoneal inoculation in syngeneic rats. The optimal concentration/time conditions for killing M5-T1 cells with curcumin were first determined in vitro. Secondly, the potential of intraperitoneal curcumin administration to kill tumor cells in vivo was evaluated in tumor-bearing rats, in comparison with a reference epigenetic drug, SAHA. Both agents administered at days 21 and 26 after tumor chal

SUBMITTER: Pouliquen DL 

PROVIDER: S-EPMC5593667 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature