A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations.

ABSTRACT: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides quantitative metrics (e.g. K^trans, v_e) via pharmacokinetic models. We tested inter-algorithm variability in these quantitative metrics with 11 published DCE-MRI algorithms, all implementing Tofts-Kermode or extended Tofts pharmacokinetic models. Digital reference objects (DROs) with known K^trans and v_e values were used to assess performance at varying noise levels. Additionally, DCE-MRI data from 15 head and neck squamous cell carcinoma patients over 3 time-points during chemoradiotherapy were used to ascertain K^trans and v_e kinetic trends across algorithms. Algorithms performed well (less than 3% average error) when no noise was present in the DRO. With

SUBMITTER: Joint Head and Neck Radiotherapy-MRI Development Cooperative 

PROVIDER: S-EPMC5593829 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature