Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy.

ABSTRACT: The comprehension of unconventional immune functions of tonsillar B cells, their role in tolerance induction and protective immune responses, is crucial to unveil the dynamic interactions of the upper aero digestive tract with polymicrobial commensal flora and pathogens, in health and disease. Here, we describe the kinetics of IL10 intracellular expression and compare it with that of cytokines known to be produced by tonsillar B cells. Additionally, we detected a relevant proportion of IL17-expressing tonsillar B cells, which has not previously been reported. We immunophenotyped tonsillar IL10-expressing B cells (B10) and observed IL10 production in activated B cells at every developmental stage. Finally, we identified a relationship between decreased B10 percentages, increased proportion

SUBMITTER: Sarmiento Varon L 

PROVIDER: S-EPMC5593840 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature