The parathyroid hormone regulates skin tumour susceptibility in mice.

ABSTRACT: Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Sub-congenic mapping localized Parathyroid hormone (Pth) in Stmm1b. Here, we report that serum intact-PTH (iPTH) and a genetic polymorphism in Pth are important for skin tumour resistance. We identified higher iPTH levels in sera from cancer-resistant MSM/Ms mice compared with susceptible FVB/NJ mice. Therefore, we performed skin carcinogenesis experiments with MSM-BAC transgenic mice (Pth ^MSM-Tg) and Pth knockout heterozygous mice (Pth ^+/-). As a result, the higher amounts of iPTH in sera conferred stronger resistance to skin tumours. Furthermore, we found that

SUBMITTER: Okumura K 

PROVIDER: S-EPMC5593851 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature