Flavonoid allosteric modulation of mutated visual rhodopsin associated with retinitis pigmentosa.

ABSTRACT: Dietary flavonoids exhibit many biologically-relevant functions and can potentially have beneficial effects in the treatment of pathological conditions. In spite of its well known antioxidant properties, scarce structural information is available on the interaction of flavonoids with membrane receptors. Advances in the structural biology of a specific class of membrane receptors, the G protein-coupled receptors, have significantly increased our understanding of drug action and paved the way for developing improved therapeutic approaches. We have analyzed the effect of the flavonoid quercetin on the conformation, stability and function of the G protein-coupled receptor rhodopsin, and the G90V mutant associated with the retinal degenerative disease retinitis pigmentosa. By using a combinatio

SUBMITTER: Herrera-Hernandez MG 

PROVIDER: S-EPMC5593859 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature