Lactate-utilizing community is associated with gut microbiota dysbiosis in colicky infants.

ABSTRACT: The aetiology of colic, a functional gastrointestinal disorder in infants, is not yet resolved. Different mechanisms have been suggested involving the gut microbiota and intermediate metabolites such as lactate. Lactate can be metabolized by lactate-utilizing bacteria (LUB) to form different end-products. Using a functional approach, we hypothesized that H₂ production and accumulation by LUB is associated with the development of colic. The LUB communities in the feces of forty infants, including eight colicky infants, were characterized using a combination of culture- and molecular-based methods, and metabolite concentrations were measured by HPLC. Interactions among LUB strains isolated from feces were investigated with pure and mixed cultures using anaerobic techniques. We emp

SUBMITTER: Pham VT 

PROVIDER: S-EPMC5593888 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature