Ultraviolet Radiation-Induced Production of Nitric Oxide:A multi-cell and multi-donor analysis.

ABSTRACT: Increasing evidence regarding positive effects of exposure to sunlight has led to suggestions that current advice may be overly weighted in favour of avoidance. UV-A has been reported to lower blood pressure, possibly through nitric oxide (NO) production in skin. Here, we set out to investigate effects of UV-A and solar-simulated radiation on the potential source of dermal NO, the effective doses and wavelengths, the responsiveness of different human skin cells, the magnitude of inter-individual differences and the potential influence of age. We utilised isogenic keratinocytes, microvascular endothelial cells, melanocytes and fibroblasts isolated from 36 human skins ranging from neonates to 86 years old. We show that keratinocytes and microvascular endothelial cells show greatest NO releas

SUBMITTER: Holliman G 

PROVIDER: S-EPMC5593895 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature