Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes.

ABSTRACT:

Background

The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway has been well-characterized as a crucial signal transduction cascade that regulates vital biological responses including development, immunity and oncogenesis. Additionally to its canonical pathway that uses the phosphorylated form of the STAT transcription factor, recently the non-canonical pathway involving heterochromatin formation by unphosphorylated STAT was recently uncovered. Considering the significant role of the JAK/STAT pathway, we used the simple Drosophila system in which the non-canonical pathway was initially characterized, to compare putative canonical versus non-canonical transcriptional targets across the genome. We analyzed microarray expression patterns of wildtype, J

SUBMITTER: Tsurumi A 

PROVIDER: S-EPMC5594485 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature