Involvement of DPP9 in gene fusions in serous ovarian carcinoma.

ABSTRACT:

Background

A fusion gene is a hybrid gene consisting of parts from two previously independent genes. Chromosomal rearrangements leading to gene breakage are frequent in high-grade serous ovarian carcinomas and have been reported as a common mechanism for inactivating tumor suppressor genes. However, no fusion genes have been repeatedly reported to be recurrent driver events in ovarian carcinogenesis. We combined genomic and transcriptomic information to identify novel fusion gene candidates and aberrantly expressed genes in ovarian carcinomas.

Methods

Examined were 19 previously karyotyped ovarian carcinomas (18 of the serous histotype and one undifferentiated). First, karyotypic aberrations were compared to fusion gene candidates identified by RNA sequencing (RNA-seq). In a

SUBMITTER: Smebye ML 

PROVIDER: S-EPMC5594496 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature