Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation.

ABSTRACT:

Background

Exposure to particulate matter (PM) is associated with increased incidence of cardiovascular disease and increased coagulation, but the molecular mechanisms underlying these associations remain unknown. Obesity may increase susceptibility to the adverse effects of PM exposure, exacerbating the effects on cardiovascular diseases. Extracellular vesicles (EVs), which travel in body fluids and transfer microRNAs (miRNAs) between tissues, might play an important role in PM-induced cardiovascular risk. We sought to determine whether the levels of PM with an aerodynamic diameter ≤ 10 μm (PM₁₀) are associated with changes in fibrinogen levels, EV release, and the miRNA content of EVs (EV-miRNAs), investigating 1630 overweight/obese subjects from the SPHERE Study.

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SUBMITTER: Pergoli L 

PROVIDER: S-EPMC5594543 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature