Developing genome-reduced Pseudomonas chlororaphis strains for the production of secondary metabolites.

ABSTRACT:

Background

The current chassis organisms or various types of cell factories have considerable advantages and disadvantages. Therefore, it is necessary to develop various chassis for an efficient production of different bioproducts from renewable resources. In this context, synthetic biology offers unique potentialities to produce value-added products of interests. Microbial genome reduction and modification are important strategies for constructing cellular chassis and cell factories. Many genome-reduced strains from Escherichia coli, Bacillus subtilis, Corynebacterium glutamicum and Streptomyces, have been widely used for the production of amino acids, organic acids, and some enzymes. Some Pseudomonas strains could serve as good candidates for ideal chassis cells since they grow f

SUBMITTER: Shen X 

PROVIDER: S-EPMC5594592 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature