Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.

ABSTRACT: When food resources are scarce, endothermic animals can lower core body temperature (T_b). This phenomenon is believed to be part of an adaptive mechanism that may have evolved to conserve energy until more food becomes available. Here, we found in the mouse that the insulin-like growth factor 1 receptor (IGF-1R) controls this response in the central nervous system. Pharmacological or genetic inhibition of IGF-1R enhanced the reduction of temperature and of energy expenditure during calorie restriction. Full blockade of IGF-1R affected female and male mice similarly. In contrast, genetic IGF-1R dosage was effective only in females, where it also induced transient and estrus-specific hypothermia in animals fed ad libitum. These effects were regulated in the brain, as only central,

SUBMITTER: Cintron-Colon R 

PROVIDER: S-EPMC5594635 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature