Metal-mediated diradical tuning for DNA replication arrest via template strand scission.

ABSTRACT: A series of M(PyED)·X (X = 2Cl^-, SO₄^2-) pyridine-metalloenediyne complexes [M = Cu(II), Fe(II), or Zn(II)] and their independently synthesized, cyclized analogs have been prepared to investigate their potential as radical-generating DNA-damaging agents. All complexes possess a 1:1 metal-to-ligand stoichiometry as determined by electronic absorption spectroscopy and X-ray diffraction. Solution structural analysis reveals a pπ Cl [Formula: see text] Cu(II) LMCT (22,026 cm^-1) for Cu(PyED)·2Cl, indicating three nitrogens and a chloride in the psuedo-equatorial plane with the remaining pyridine nitrogen and solvent in axial positions. EPR spectra of the Cu(II) complexes exhibit an axially elongated octahedron. This spectroscopic evidence, together wit

SUBMITTER: Porter MR 

PROVIDER: S-EPMC5594643 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature