Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. DLBCL exhibits highly aggressive and systemic progression into multiple tissues in patients, particularly in lymph nodes. Whole-body ¹⁸F-fluodeoxyglucose positron emission tomography ([¹⁸F]FDG-PET) imaging has an essential role in diagnosing DLBCL in the clinic; however, [¹⁸F]FDG-PET often faces difficulty in differentiating malignant tissues from certain nonmalignant tissues with high glucose uptake. We have developed a PET imaging strategy for DLBCL that targets poly[ADP ribose] polymerase 1 (PARP1), the expression of which has been found to be much higher in DLBCL than in healthy tissues. In a syngeneic DLBCL mouse model, this PARP1-targeted PET imaging approach allowed us to di

SUBMITTER: Tang J 

PROVIDER: S-EPMC5594659 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature